Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline - PubMed
6 hours ago
- #Alzheimer's disease
- #Neurodegenerative Diseases
- #Glymphatic System
- Neurotoxic protein accumulation is a key feature of Alzheimer's disease.
- Impaired brain clearance due to dysfunction of meningeal lymphatic and glymphatic systems may contribute to protein buildup.
- Therapeutic approaches include pharmacological targeting of aquaporin-4 or VEGF-C signaling, and non-invasive methods like photobiomodulation and focused ultrasound.
- Surgical or lifestyle interventions to enhance drainage, such as deep cervical lymphovenous anastomosis, show preliminary proof but need validation.
- Developing sensitive, non-invasive imaging markers and defining intervention windows are crucial for progress.
- Lymphatic reconstruction is considered a potential therapeutic direction within multimodal strategies for Alzheimer's disease.