Osteogenic Nanozymes for Diabetic Bone Regeneration via Synergistic Antioxidant and Osteoinductive Functions - PubMed
5 hours ago
- #nanozymes
- #diabetic bone regeneration
- #osteogenic differentiation
- Diabetic bone regeneration is challenging due to oxidative stress, inflammation, and impaired osteogenic potential.
- Nanozymes, like copper-doped Prussian blue (CuPB), combine antioxidant and osteoinductive properties for bone repair.
- CuPB nanozymes scavenge reactive oxygen species, reduce inflammation, and promote osteogenic differentiation via the PI3K-Akt pathway.
- In diabetic rat models, CuPB enhances bone regeneration in alveolar bone loss and cranial defects.
- The study introduces an 'osteogenic nanozyme' platform integrating antioxidant and osteoinductive functions.