LOX-1 gene knockout improves metabolic dysfunction - associated steatohepatitis in mice - PubMed
5 hours ago
- #Liver fibrosis
- #MASH
- #LOX-1 knockout
- LOX-1 gene knockout alleviates Western diet-induced metabolic dysfunction-associated steatohepatitis (MASH) in mice.
- LOX-1 mRNA is upregulated in mouse models of high-fat diet and bile duct ligation.
- Knockout of LOX-1 reduces serum AST and ALT levels, liver inflammation, steatosis, fibrosis, and lipid accumulation.
- LOX-1 silencing in LX-2 cells decreases fibrogenic marker genes (Acta2, Col1a1, Timp1) and α-SMA expression.
- Network pharmacology suggests LOX-1 may promote MASH via lipid and cholesterol metabolism networks.