Maternal Thyroid Disorders and Their Effects on the Metabolic Profile of Breast Milk: A Systematic Review - PubMed
6 hours ago
- #breast milk composition
- #neonatal health
- #maternal thyroid disorders
- Maternal thyroid disorders significantly alter the lipidome of breast milk, increasing saturated fatty acids and depleting neurocritical lipids like glycerophospholipids and nervonic acid.
- Hypothyroidism in mothers is linked to reduced total protein content in breast milk and downregulation of membrane proteins such as adipophilin and butyrophilin.
- Thyroid dysfunction correlates with decreased levels of sialylated oligosaccharides in breast milk, while specific immune modulators like the Ig gamma-3 chain are upregulated.
- Maternal thyroid disorders may lead to adverse metabolic programming in neonates, predisposing them to cognitive deficits and metabolic disorders.
- Strict management of maternal thyroid health is essential to preserve the biological quality of breast milk and optimize neonatal outcomes.