Bilateral bifoveate retina in a human resembling lizard foveal architecture - PubMed
4 hours ago
- #retina
- #ophthalmology
- #fovea
- A 45-year-old man was found to have bilateral bifoveate retinas, an extremely rare human condition.
- Each eye had two distinct foveal pits: a deep central fovea and a shallower temporal fovea with grade 1 foveal hypoplasia.
- OCT-angiography showed paired foveal avascular zones in both eyes, unlike typical unilateral and nonfunctional cases.
- The temporal foveae displayed well-developed architecture similar to the bifoveate visual system of Anolis lizards.
- The case may result from a partial failure of CYP26A1-mediated retinoic acid signaling, which normally restricts fovea formation to one site in primates.