Deciphering the toxicological mechanism of airway allergic diseases caused by dioctyl terephthalate: a composite study - PubMed
6 hours ago
- #plasticizer
- #airway allergic diseases
- #immunotoxicity
- DOTP, a plasticizer alternative, may have immunotoxic effects on airway allergic diseases like AR, AS, CRS, and ABPA, though these are unclear.
- A composite study using network toxicology, bioinformatics, and machine learning identified 136 shared targets between DOTP and allergic diseases, involved in immune and apoptotic pathways.
- Core genes implicated include EGFR, BCL2, CFTR, SYK, and C3AR1, with DOTP showing strong binding affinity in molecular docking analyses.
- In vitro validation with human airway epithelial cells confirmed DOTP-induced cytotoxicity and changes in gene expression of these targets.
- DOTP exhibits potential toxicities such as carcinogenicity and nephrotoxicity, suggesting it may promote allergic airway diseases through multi-target immune-related mechanisms.
- The findings highlight health risks from DOTP exposure and call for further investigation into its toxicological role in allergic conditions.