Exogenous Nitric Oxide in the Treatment of Dental and Oral Diseases - PubMed

5 hours ago

Nitric oxide (NO) plays a central role in dental and oral diseases due to its signaling properties.
Exogenous NO therapy is explored for its antibacterial, anti-inflammatory, tissue-regenerative, and antitumor effects.
Key mechanisms include modulation of cyclic di-guanosine monophosphate, S-nitrosylation, and activation of guanylate cyclase pathways.
NO delivery platforms like nanocarriers, hydrogels, and implant coatings are reviewed for various dental applications.
Applications include periodontitis, dental caries, oral ulcers, orthodontic tooth movement, and oral cancer treatment.
Most evidence comes from preclinical studies, with challenges in dosing accuracy and delivery specificity.
Exogenous NO shows promise as an adjunctive therapy in dental medicine despite current limitations.

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