Spatiotemporally controlled restoration of GAS6 signaling via mRNA therapy promotes scarless healing in preclinical models - PubMed
6 hours ago
- #fibrosis
- #mRNA therapy
- #wound healing
- GAS6 signaling plays a key role in immune-fibroblast crosstalk during wound healing.
- A lipid nanoparticle (LNP)-mRNA hydrogel platform was developed for spatiotemporally controlled delivery of GAS6 mRNA.
- The treatment enhances macrophage efferocytosis and suppresses inflammatory fibroblasts.
- Tested in murine, rabbit ear, and Bama minipig models, the therapy accelerates wound closure and reduces fibrotic scarring.
- The approach offers a promising therapeutic strategy for fibrotic skin disorders.