A DYRK inhibitor ameliorates glucose homeostasis and increases incretin-producing cells in diabetic mice - PubMed
4 days ago
- #DYRK inhibitor
- #incretin therapy
- #diabetes treatment
- A DYRK inhibitor, ID-8, improves glucose homeostasis in diabetic db/db mice.
- ID-8 treatment reduces HbA1c and blood glucose levels post-glucose tolerance test.
- Plasma levels of insulin, total-GIP, and total-GLP-1 are enhanced with ID-8.
- Increased numbers of intestinal K-cells and L-cells observed in treated mice.
- Some K-cells and L-cells co-stained with NFATc4, a DYRK-regulated factor.
- No significant change in pancreatic β- and α-cell mass between treated and control mice.
- ID-8 increases mRNA levels of incretins in human intestinal organoids.
- Potential novel therapeutic agent for diabetes due to incretin-enhancing effects.