Prevalence and clinical correlates of infection in idiopathic inflammatory myopathies: A systematic review and meta-analysis of 14,548 patients - PubMed
4 hours ago
- #idiopathic inflammatory myopathies
- #infection risk
- #systematic review
- The pooled infection prevalence in patients with idiopathic inflammatory myopathies (IIMs) was 24% (95% CI: 18-31%).
- Respiratory tract infections were the most common site; Pneumocystis jirovecii pneumonia (PJP), aspergillosis, and herpes zoster were prevalent pathogens.
- Risk factors for infection included older age, male sex, diabetes, hypertension, anti-MDA5 positivity, rapidly progressive interstitial lung disease (RPILD), dermatomyositis, skin ulcerations, dysphonia, lower lymphocyte counts, lower albumin, lower hemoglobin, higher initial glucocorticoid dose, methylprednisolone pulse, cyclophosphamide, azathioprine, and intravenous immunoglobulin.
- Factors associated with reduced infection risk included TMP-SMX prophylaxis, anti-TIF1-γ positivity, and polymyositis phenotype.
- The study highlights the multifactorial nature of infection risk in IIMs and recommends systematic risk stratification and targeted prophylaxis to reduce morbidity and mortality.