BAF60C links nucleolar stress to β cell dysfunction in type 2 diabetes through controlling Reg3b mRNA decay - PubMed
14 hours ago
- #β cell dysfunction
- #BAF60C
- #type 2 diabetes
- BAF60C links nucleolar stress to β cell dysfunction in type 2 diabetes (T2D).
- Reduced BAF60C expression correlates with β cell dysfunction in T2D patients and diabetic mice.
- BAF60C deletion in β cells worsens high-fat diet-induced hyperglycemia, nucleolar stress, and islet inflammation.
- BAF60C overexpression protects against these effects.
- BAF60C promotes REG3B expression and secretion, modulating β cell-macrophage crosstalk.
- BAF60C forms an RNA-protein complex with NPM1 and Reg3b mRNA to regulate mRNA decay.
- Restoring the BAF60C-REG3B axis improves glucose homeostasis in obese and T2D mice.