Long-term Western diet feeding impairs hepatic vitamin D metabolism and promotes bone loss in mice - PubMed
6 hours ago
- #Vitamin D
- #Bone Loss
- #Liver-Bone Axis
- Long-term Western diet (WD) feeding in mice leads to obesity, hepatic injury, and trabecular bone deterioration.
- WD-fed mice showed reduced bone mineral density and increased trabecular separation, but no significant impairment in cortical bone mechanical properties.
- Histological analyses revealed increased bone marrow adiposity and macrophage/monocyte lineage cells in WD-fed mice.
- Bone gene expression profiling indicated enhanced osteoclastogenic signaling in WD-fed mice.
- Hepatic transcriptomics showed downregulation of key 25-hydroxylases (Cyp2r1, Cyp27a1) and vitamin D-binding protein, leading to reduced circulating 25-hydroxyvitamin D.
- Bone tissue exhibited decreased vitamin D receptor (VDR) protein abundance in WD-fed mice.
- The study suggests that WD-induced obesity and hepatic dysfunction impair hepatic vitamin D metabolism and diminish skeletal vitamin D responsiveness, contributing to bone fragility.
- Targeting the liver-bone axis and restoring vitamin D homeostasis may offer therapeutic potential for obesity-related bone loss.