Macrophages in colorectal cancer: origin, function and significance of targeted therapy - PubMed
2 hours ago
- #Tumor-Associated Macrophages
- #Targeted Therapy
- #Colorectal Cancer
- Colorectal cancer (CRC) is influenced by the tumor microenvironment (TME), where tumor-associated macrophages (TAMs) are key components and potential therapeutic targets.
- The roles of TAMs in CRC are controversial and linked to their high plasticity, which this review explores through their origins, classifications, and functions in CRC progression.
- The review summarizes current CRC treatment strategies targeting TAMs to advance precision-targeted therapy and provide new perspectives for personalized CRC treatment.