Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation - PubMed
5 days ago
- #Hippo-YAP
- #spindle-misorientation
- #epithelial-tissue
- Multicellular organisms have safeguard mechanisms to maintain tissue integrity.
- Spindle misorientation can lead to cell mispositioning and loss in epithelial tissues.
- Non-centrosomal microtubules and cell contractility help reintegrate mispositioned cells.
- Tissue mechanics and cell-size sensing reduce apoptosis via Hippo/YAP signaling.
- Systemic TNF signaling eliminates harmful non-reintegrating cells.
- Mechanics and systemic signaling work together to control cell number and position.