The conserved fibroblast growth factor receptor-based signaling is required for dendrite regeneration - PubMed
5 hours ago
- #dendrite regeneration
- #FGFR signaling
- #C. elegans
- The study developed a high-throughput method to induce dendrite injury in the PVD neuron of Caenorhabditis elegans.
- A screen of 825 genes highly expressed in PVD neurons identified key regulators of dendrite regeneration, including FGFR/EGL-15.
- FGFR/EGL-15 is necessary and sufficient within the neuron early after injury to initiate branching from the broken dendrite tip.
- FGFR/EGL-15 is also required in the epidermal tissue to prevent distal dendrite degeneration.
- The FGF ligand EGL-17 functions within the surrounding epithelia for the neuron-specific role of EGL-15.
- Downstream of EGL-15, the GRB2/SEM-5 adaptor-dependent signaling arm involving GEF/SOS-1, RAS/LET-60, and MAPK-1/MPK-1 is required for dendrite regeneration.
- The study identified conserved FGFR signaling as a key responder to dendrite injury to initiate regeneration.
- Pathways involving F-actin dynamics and transcription factors were also identified, aiding future research into dendrite regeneration mechanisms.