A prospective, multicenter cohort study to identify unmet medical needs in Japanese patients with chronic obstructive pulmonary disease: The J-UNMET-COPD study protocol - PubMed
6 hours ago
- #Biomarkers
- #COPD
- #Clinical Study
- A prospective cohort study in Japan, the J-UNMET-COPD study, aims to identify unmet medical needs in COPD patients.
- It will enroll 300 optimally treated COPD patients, 100 on monotherapy, and 100 non-COPD controls from five centers.
- Participants undergo comprehensive assessments over three years, including spirometry, CT imaging, blood tests, transcriptomics, proteomics, cardiovascular biomarkers, and frailty evaluation.
- Primary endpoint compares three-year exacerbation frequencies stratified by blood eosinophil counts.
- Secondary endpoints aim to find clinical and molecular predictors of treatment response and disease stability.
- Goal is to enable precision medicine strategies and proactive, personalized COPD management.