African swine fever virus pC147L inhibits retinoic acid-inducible gene I-like receptors pathway via targeting MAVS-TRAF6 complex - PubMed
5 hours ago
- #vaccine development
- #African swine fever virus
- #innate immunity
- ASFV pC147L inhibits the RIG-I-like receptors (RLRs) pathway by targeting the MAVS-TRAF6 complex.
- pC147L specifically blocks RLRs-mediated IFN-β production without affecting TLR3 or cGAS-STING pathways.
- Mechanistically, pC147L disrupts MAVS-TRAF6 complex formation, preventing TBK1 recruitment and MAVS signalosome assembly.
- Overexpression of pC147L enhances ASFV replication by suppressing type I IFN responses in porcine alveolar macrophages (PAMs).
- The study identifies pC147L as a potential target for ASFV vaccine development due to its role in immune evasion.