Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk - PubMed
5 hours ago
- #genetics
- #autoimmunity
- #cancer
- Genome-wide association meta-analysis of 81,718 autoimmune hypothyroidism (AIHT) cases identified 418 independent signals.
- 48 loci have protein-coding variants, including Finnish-enriched variants in LAG3, ZAP70, and TG.
- ZAP70:T155M variant reduces T cell activation.
- 38% of loci are involved in general autoimmunity, while 20% are thyroid-specific.
- 10% of AIHT loci show protective effects against skin cancer, indicating antagonistic pleiotropy.
- Findings support the role of natural immune variation in influencing cancer outcomes.