MPND Loss Epigenetically Activates TGF-β/SMAD3 Signaling to Drive Tumor Progression and Metastasis in Non-small Cell Lung Cancer - PubMed
2 hours ago
- #epigenetics
- #TGF-beta signaling
- #NSCLC
- MPND is a deubiquitinase often deleted and downregulated in NSCLC, correlating with poor clinical outcomes.
- Loss of MPND promotes cell migration, invasion, and cancer stem cell traits by elevating H2A and H2B ubiquitination.
- MPND depletion epigenetically activates TGF-β/SMAD3 signaling, enhancing chromatin accessibility at the SMAD3 locus.
- In vivo and clinical data confirm that MPND loss drives NSCLC tumor growth and metastasis via TGF-β/SMAD3.
- Targeting the TGF-β/SMAD3 axis may be a promising therapeutic strategy for MPND-deficient NSCLC tumors.