Spatial Transcriptomics Reveals Location-Specific Tumor Cell Subtypes and Signaling within Multifocal Small Intestinal Neuroendocrine Tumors - PubMed
5 hours ago
- #neuroendocrine tumors
- #spatial transcriptomics
- #tumor heterogeneity
- Spatial transcriptomics identifies four distinct tumor cell subtypes in multifocal small intestinal neuroendocrine tumors (SI-NETs) based on anatomical location.
- The subtypes are 'mucosal', 'mesenteric', 'lymphatic', and 'deep', each with unique gene expression patterns and ligand-receptor interactions.
- Key signaling pairs like NRG1-ERBB3 (mesenteric), CXCL12-CXCR4 (lymphatic), and SST-SSTR1/2 (common across subtypes) were identified.
- Findings suggest local microenvironment influences tumor development and heterogeneity, offering potential for subtype-targeted therapies.