Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection - PubMed
5 hours ago
- #FcγR interaction
- #PD-1 immunotherapy
- #CD8 T cell depletion
- Mouse anti-mouse PD-1 antibodies with an intact Fc region selectively deplete PD-1+ virus-specific CD8 T cells in the liver during chronic infection.
- This depletion is mediated by activating FcγR III on phagocytic cells, not natural killer cells, leading to increased viral titers and reduced tumor control in models.
- Mutating the Fc region to block FcγR interaction prevents CD8 T cell depletion, resulting in effective immunotherapy.
- Fc-intact anti-PD-1 antibodies may have negative effects in liver cancer, liver metastases, and chronic hepatotropic infections, but could benefit agonistic antibodies in autoimmunity.
- The findings emphasize the critical role of the antibody Fc region in tailoring PD-1 therapies for different clinical applications.