Sustained-release CGRP microspheres accelerate diabetic wound healing by synergistically promoting neurovascular regeneration through modulation of macrophage and endothelial cell functions - PubMed
6 hours ago
- #CGRP microspheres
- #diabetic wound healing
- #neurovascular regeneration
- Sustained-release CGRP microspheres (BA-HPCS@CGRP) accelerate diabetic wound healing.
- CGRP expression is downregulated in diabetic skin tissues, indicating its crucial role in wound healing.
- Microspheres enhance endothelial cell migration and tube formation under high-glucose conditions.
- CGRP promotes macrophage polarization to M2 phenotype, increasing secretion of Angptl4 to aid endothelial function.
- In diabetic mouse models, BA-HPCS@CGRP reduces inflammation and promotes neurovascular regeneration.
- The therapy synergistically modulates the 'neuro-immune-vascular' axis for comprehensive sequential treatment.
- This approach offers a novel therapeutic strategy for diabetic wounds through low-concentration CGRP release.