Aged garlic extract suppressed macrophage-mediated inflammation in acute respiratory distress syndrome - PubMed
4 hours ago
- #macrophage
- #acute respiratory distress syndrome
- #anti-inflammatory
- Aged garlic extract (AGE) combined with low-dose dexamethasone (DEX) enhanced anti-inflammatory effects in acute respiratory distress syndrome (ARDS).
- The combination therapy inhibited inflammatory cytokines and NF-κB signaling in M1 macrophages more effectively than monotherapy.
- In an ARDS mouse model, AGE plus DEX reduced body weight loss, inflammatory cell infiltration, and lung injury, suggesting a safer alternative to high-dose steroids.