Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases - PubMed
6 days ago
- #pharmacovigilance
- #drug-safety
- #male-infertility
- Study identifies 19 high-risk drugs linked to male infertility using FAERS and EudraVigilance databases.
- Key drugs include hormonal agents (finasteride, dutasteride, testosterone), antineoplastic drugs (bleomycin, vinblastine), and antidepressants (citalopram, paroxetine).
- Median time to event onset was 132 days, aligning with the spermatogenic cycle.
- Finasteride showed strong causality evidence through dechallenge/rechallenge analyses.
- Recommendations include pre-prescription fertility counseling and sperm cryopreservation before chemotherapy.