The impact of levodopa on post-stroke depression: the ESTREL-depression-study - PubMed
5 days ago
- #depression
- #stroke
- #levodopa
- The study investigated the impact of levodopa on post-stroke depression (PSD) in stroke patients undergoing rehabilitation.
- ESTREL-Depression was a pre-planned analysis of a multicenter, randomized, double-blind, placebo-controlled trial involving 407 participants.
- Participants received either levodopa/carbidopa or placebo three times daily for 39 days, with PSD assessed 3 months post-randomization.
- Results showed no significant difference in PSD occurrence between the levodopa group (26%) and placebo group (28%).
- The study concluded that levodopa treatment did not affect the occurrence of PSD in stroke patients.