CDCA7 targets LSH to DNA maintenance methylation in S phase and transcription regulation in interphase via two distinct DNA-binding modes - PubMed
4 hours ago
- #DNA methylation
- #ICF syndrome
- #CDCA7
- CDCA7 mutations cause ICF syndrome and it binds to both CG-rich DNA and hemimethylated DNA.
- CDCA7 localizes differently during the cell cycle: nuclear in interphase and heterochromatin in S phase.
- CDCA7 recruits LSH to CG-rich promoters in interphase and heterochromatin in S phase.
- CDCA7 and LSH are essential for DNA maintenance methylation and also regulate transcription independently of DNA methylation.
- The study reveals new functions of CDCA7/LSH in gene expression beyond DNA methylation, impacting understanding of ICF syndrome.