Exploring the association between 5 different alternative indicators of insulin resistance and the risk of multiple cardiovascular and metabolic diseases: A cross-sectional NHANES study from 2005 to 2
4 hours ago
- #cardiometabolic multimorbidity
- #NHANES study
- #insulin resistance
- Study explores the link between 5 insulin resistance (IR) surrogates and cardiometabolic multimorbidity (CMM) risk.
- Data from NHANES 2005-2018 was analyzed, involving 15,537 participants, with 2,881 developing CMM.
- Higher levels of IR markers (TyG index, TyG-BMI, METS-IR, TG/HDL-C, HOMA-IR) were significantly associated with increased CMM risk.
- Trend analysis showed a dose-response relationship, while restricted cubic spline analysis revealed J-shaped nonlinear relationships for TyG index and HOMA-IR.
- HOMA-IR had the highest predictive performance for CMM risk (AUC: 0.699).
- The study suggests HOMA-IR as the optimal surrogate index for IR in relation to CMM risk.