Sodium hyaluronate based multifunctional hydrogels delivering SiRNA for sustained silencing of SMAD3: A novel strategy to treat intrauterine adhesions - PubMed
6 hours ago
- #Endometrial regeneration
- #siRNA delivery
- #Intrauterine adhesion
- Sodium hyaluronate-based hydrogels deliver siRNA to silence SMAD3 for treating intrauterine adhesions (IUA).
- The hydrogel (QOHP@siRNA) addresses siRNA challenges like poor uptake, short half-life, and rapid degradation.
- Exhibits antibacterial activity against gram-negative bacilli and gram-positive cocci.
- Promotes endometrial angiogenesis, cellular proliferation, and restores fertility.
- Shows potential for gene delivery-based therapies beyond IUA.