Omega-3 polyunsaturated fatty acid exposure and cardiovascular outcomes in dialysis: a systematic review and meta-analysis - PubMed
5 hours ago
- #cardiovascular outcomes
- #dialysis
- #omega-3
- Patients with dialysis-dependent chronic kidney disease (CKD) have a high cardiovascular burden.
- Fish oil or long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) are potential risk-reducing therapies.
- A systematic review and meta-analysis assessed associations between n-3 PUFA exposure and cardiovascular outcomes or all-cause mortality in dialysis patients.
- Fish oil supplementation in hemodialysis-dependent CKD lowered cardiovascular events by 44% and myocardial infarction by 48%.
- Higher baseline n-3 PUFA levels were associated with a 31% reduction in all-cause mortality.
- Higher dietary n-3 PUFA intake showed a non-significant trend toward lower all-cause mortality.
- Omega-3 supplements likely offer benefits for hemodialysis patients, but further large studies are needed for confirmation.