Elucidating the potential carcinogenic molecular mechanisms of parabens in head and neck squamous cell carcinoma through network toxicology and molecular docking - PubMed
5 hours ago
- #parabens
- #carcinogenesis
- #HNSCC
- Study investigates molecular mechanisms of parabens in head and neck squamous cell carcinoma (HNSCC) using network toxicology and molecular docking.
- Six parabens (ethyl-, propyl-, methyl-, heptyl-, butyl-, and benzylparaben) were analyzed for toxicity prediction and potential targets.
- Identified 80 common targets linking parabens to HNSCC, with 12 hub genes (e.g., CCNB1, CDK1, CCNA2) overexpressed in HNSCC tissues.
- Hub genes are involved in cell cycle regulation, p53 signaling, and viral carcinogenesis pathways.
- CCNA1 was validated as an independent prognostic factor associated with poor survival.
- Molecular docking showed strong binding affinities between parabens and hub proteins.
- Immune infiltration analysis revealed a negative correlation between CCNA1 expression and CD8+ T cell and B cell infiltration.
- Parabens may promote HNSCC progression by disrupting cell cycle regulation and immune responses.
- Findings highlight the carcinogenic potential of parabens in HNSCC, requiring further validation.