Macrophages at the Core: Metabolic shifts and renal cell cross-talk as key mediators in diabetic nephropathy - PubMed
14 hours ago
- #Diabetic nephropathy
- #Macrophages
- #Metabolism
- Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, driven by chronic immune activation and metabolic imbalance.
- Macrophages are central regulators in DN, undergoing metabolic reprogramming in glucose, lipid, and protein metabolism.
- Macrophages mediate renal inflammation, oxidative stress, and fibrosis, linking metabolic changes to kidney damage.
- Combination metabolic interventions are needed due to the complexity of macrophage reprogramming.
- Macrophages communicate with renal cells, coordinating immune-metabolic coupling and disease progression.
- Emerging therapies include exosome-based delivery, physical modulation, and microenvironmental reprogramming.
- The review highlights macrophages as key targets for precision intervention in DN.