MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway - PubMed
6 hours ago
- #MAPK Pathway
- #MOTS-c
- #Liver Injury
- MOTS-c, a mitochondrial-derived peptide, shows hepatoprotective effects against acetaminophen (APAP)-induced liver injury (AILI).
- The study used an AILI mouse model with APAP injection (300 mg/kg) to evaluate MOTS-c's therapeutic potential.
- MOTS-c administration reduced liver damage markers (AST, ALT), histopathological damage, and pro-inflammatory factors (TNF-α, IL-1β, IL-6, COX-2).
- MOTS-c treatment restored glutathione (GSH) levels, reduced reactive oxygen species (ROS), and oxidative stress.
- TUNEL staining showed MOTS-c significantly decreased APAP-induced apoptosis in liver cells.
- Mechanistically, MOTS-c inhibited phosphorylation of MAPK pathway components (ERK, JNK, p38), and its protective effects were reversed by MAPK inhibitors.
- The study concludes MOTS-c protects against AILI by suppressing oxidative stress, inflammation, and cell death via the MAPK pathway.