Long-term remission of neuromyelitis optica with allogeneic hematopoietic stem cell transplant - PubMed
5 hours ago
- #Hematopoietic Stem Cell Transplant
- #Immune Reconstitution
- #Neuromyelitis Optica
- Two patients with treatment-refractory AQP4-IgG-positive NMO achieved long-term remission after allogeneic hematopoietic stem cell transplant.
- Sustained clinical and radiological remission occurred without immunosuppressive therapy, with undetectable AQP4-IgG antibodies post-transplant.
- Immune profiling showed robust reconstitution of T and B cells, remodeling of regulatory T cells, and full donor chimerism without graft-versus-host disease.
- AlloHCT may induce durable, treatment-free remission, suggesting potential curative disease modification in select NMO cases.