Associations Between Cerebral Microbleed Patterns and Incident Dementia: The ARIC-Neurocognitive Study - PubMed
5 hours ago
- #neurocognitive study
- #cerebral microbleeds
- #dementia
- Cerebral microbleeds (CMBs) are linked to dementia, but the impact of specific patterns is unclear.
- Lobar CMBs often result from cerebral amyloid angiopathy, while subcortical CMBs indicate hypertensive causes.
- The study included 1583 participants from the ARIC-NCS cohort, with MRI scans and dementia assessments.
- Mixed and lobar±cSS CMB patterns showed increased dementia risk (HR 1.99 and 1.96, respectively).
- Subcortical-only CMBs did not significantly increase dementia risk (HR 1.04).
- Presence of cortical superficial siderosis (cSS) was associated with higher dementia risk (HR 2.57).
- Greater numbers of microbleeds across all subtypes increased dementia risk.
- Lobar and mixed CMB patterns, as well as disease burden, are associated with incident dementia.