Translating ferroptosis into oncology: challenges, opportunities and future directions - PubMed
6 hours ago
- #cell death
- #oncology
- #ferroptosis
- Ferroptosis is an oxidative, lipid peroxidation-driven form of regulated cell death.
- It can have both tumor-suppressive and tumor-promoting effects depending on the cellular context in cancer evolution.
- Clinical translation of ferroptosis-based strategies faces challenges like pharmacological limitations and tumor heterogeneity.
- Opportunities include new ferroptosis-inducing agents and biomarker-guided patient selection.
- Potential combinations with chemotherapy, radiotherapy, targeted agents, or immunotherapies are highlighted.
- A translational roadmap for integrating ferroptosis-based therapies into oncology is outlined.