Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut-Liver Bacterial Translocation and Pro-Tumorigenic Processes - PubMed
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- #extracellular vesicles
- #hepatocellular carcinoma
- #gut-liver axis
- Gut commensal Klebsiella pneumoniae extracellular vesicles (KpEVs) contain two small tRNAs (tsRNAs) that are elevated in HCC patient serum.
- These tsRNAs suppress macrophage production of nitric oxide, a key antitumor molecule.
- KpEVs efficiently reach the liver and induce immunosuppressive macrophages, facilitating bacterial translocation from the gut.
- KpEVs promote an M2-like macrophage phenotype, enhance phagocytosis, and inhibit NO production and pyroptosis.
- The study reveals K. pneumoniae uses EVs to modulate distant organ immunity, highlighting tsRNAs as potential biomarkers and therapeutic targets.