Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity - PubMed
5 hours ago
- #oocyte
- #epigenetics
- #fertility
- The Polycomb Repressive-Deubiquitinase (PR-DUB) complex, particularly BAP1, safeguards the oocyte epigenome and female fertility by restraining Polycomb activity.
- BAP1 restricts pervasive H2AK119ub1 accumulation and protects oocyte-specific broad H3K27ac domains from ectopic H3K27me3 deposition.
- Unlike its typical role in gene repression, BAP1 primarily promotes transcription during oogenesis, which is essential for oocyte developmental competence and maternal-to-zygotic transition.
- Ectopic H3K27me3 domains in BAP1-deficient oocytes persist in preimplantation embryos but resolve after implantation, without affecting genomic imprinting.
- The study highlights PR-DUB's role in protecting euchromatin from ectopic Polycomb activity rather than enforcing transcriptional repression.