Population-Scale Plasma Proteomic Profiles Associated with Chronic Periodontitis in the UK Biobank - PubMed
6 hours ago
- #plasma proteomics
- #biomarkers
- #chronic periodontitis
- Chronic periodontitis is a destructive disease leading to tooth loss, with systemic inflammation markers poorly defined.
- Study analyzed plasma proteomic data from UK Biobank (90 patients vs. 2234 controls) using Olink Explore.
- 29 out of 2151 proteins showed significant differential expression (FDR < 1.0 × 10-5).
- GDF15 was the most upregulated protein, followed by NT-proBNP, IL-6, and IGFBP4.
- Elevated TNF receptor superfamily members (TNFRSF1A/1B, TNFRSF10A/10B) and proteins involved in extracellular matrix remodeling (COL6A3, ADAM12) were found.
- IL-6 emerged as a central hub in protein-protein interaction networks.
- Findings suggest systemic plasma protein profiles linked to chronic periodontitis, potentially aiding future biomarker development.