HIF2α-induced lysyl oxidase safeguards successful pregnancy by remodelling collagens at the feto-maternal interface - PubMed
2 days ago
- #pregnancy
- #extracellular matrix
- #hypoxia
- HIF2α-induced lysyl oxidase (LOX) plays a crucial role in successful pregnancy by remodeling collagens at the feto-maternal interface.
- Physiological uterine hypoxia promotes blastocyst implantation and trophoblastic invasion via the HIF signaling pathway.
- Spatial transcriptomic technology and genetic mouse models reveal hypoxia-induced remodeling of extracellular matrices (ECMs) facilitates embryo invasion.
- HIF2α drives LOX expression, which crosslinks and stabilizes collagen I fibrils near implanted embryos.
- Uterine-specific knockout of HIF2α and LOX leads to compromised embryo invasion and female infertility.
- The study provides insights into how hypoxia governs early embryonic invasion for successful pregnancy outcomes.