Neuroinflammation and Oxidative Stress in SOD1 Animal Models of ALS: A Meta-analysis Study of Their Effects on Disease Onset and Progression - PubMed
5 hours ago
- #Oxidative Stress
- #Neuroinflammation
- #ALS
- Neuroinflammation and oxidative stress are key contributors to ALS progression in SOD1 animal models.
- A meta-analysis of 344 preclinical studies shows treatments targeting these mechanisms improve survival and motor outcomes more than delaying disease onset.
- Treatment timing is crucial, with late pre-onset interventions being most effective.
- Sex differences were observed, with male mice showing better progression metrics but worse age at onset.
- The study supports sex-balanced and stage-specific treatment strategies in preclinical ALS research.