Magnesium Deficiency Accelerates Gut Aging and Increases Susceptibility to Colitis - PubMed
5 hours ago
- #Colitis
- #Magnesium Deficiency
- #Gut Aging
- Magnesium (Mg) deficiency is linked to accelerated gut aging and increased susceptibility to colitis.
- Age-related decline in Mg levels in the gut was observed across species.
- Mg restriction worsens colitis severity and accelerates gut aging in older mice.
- Dietary Mg deficiency affects the phosphoproteome and N-glycoproteome, destabilizing adhesion complexes.
- UK Biobank data shows that higher Mg intake (334.7-420.0 mg/day) reduces the risk of gut disorders like Crohn's disease and ulcerative colitis.
- Mg supplementation may help counteract age-related gut dysfunction.