Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis - PubMed
21 hours ago
- #islet organoids
- #angiogenesis
- #hypoxia resistance
- Excessive zinc in SC-islet β cells causes oxidative modification, inhibiting AMPK activity and hindering function.
- Chemical inhibition of zinc transport activates AMPK, enhancing functional maturation and hypoxia resistance in SC-islets.
- This inhibition promotes HIF1A-independent VEGFA expression, facilitating endothelial cell integration and angiogenesis.
- In diabetic animal models, the approach improved hypoxia resistance, accelerated angiogenesis, and enhanced glycemic control.
- The findings suggest a strategy to pre-adapt SC-islets to stress, advancing regenerative medicine for diabetes treatment.