Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation - PubMed
9 hours ago
- #Bisphenol A
- #Molecular Mechanisms
- #Major Depressive Disorder
- Integrative analysis combines network toxicology, molecular docking, genetic epidemiology, and transcriptomics to explore BPA exposure links to major depressive disorder (MDD).
- Identified 571 shared targets between BPA and MDD, enriched in neurodevelopment, synaptic plasticity, and cognitive function pathways.
- Six core targets highlighted: ESR1, SRC, EGFR, AKT1, PLCG2, and JAK3, with causal roles supported for AKT1, SRC, PLCG2, and JAK3 via Mendelian randomization.
- EGFR showed a protective effect against MDD based on genetic analyses.
- Validation included single-cell RNA-seq, bulk RNA-seq, ELISA, qRT-PCR in BPA-exposed mouse models, and behavioral assessments, confirming molecular mechanisms.