Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomes - PubMed
3 hours ago
- #LRRK2
- #Centrosomes
- #Proximity Proteomics
- Proximity proteomics using BioID uncovers new LRRK2 interactors.
- Co-evolutionary analysis reveals a structural module enriched in centrosomal and microtubule components.
- AlphaFold-Multimer modeling shows LRRK2 interactions depend on specific conformations and epitopes.
- Kinase inhibitor MLi-2 and RAB29 co-expression induce distinct changes in the LRRK2 proximity proteome.
- LRRK2 activity state links it to cellular sub-compartments like centriolar satellites and vesicles.