Signaling pathways of inflammation in CIA model of rheumatoid arthritis regulated by cannabichromene - PubMed
4 hours ago
- #Inflammasome
- #Rheumatoid Arthritis
- #Cannabichromene
- Cannabichromene (CBC) shows anti-inflammatory effects in rheumatoid arthritis.
- CBC reduces TNF-α expression in vitro and decreases arthritis scores in a CIA rat model.
- It downregulates IL-6, STAT3, IL-17A, and inflammasome components like NLRP3.
- CBC does not significantly affect paw swelling or MMP-3 and MMP-9 levels.
- The study suggests CBC modulates the TNF-NF-κB-IL-6-STAT3-Th17 axis.