ZEB1 integrates stemness, differentiation blockade and immune suppression to orchestrate osteosarcoma aggressiveness - PubMed

4 hours ago

ZEB1 plays a crucial role in osteosarcoma aggressiveness by integrating stemness, differentiation blockade, and immune suppression.
In OS models, ZEB1 loss reduces stemness, impairs growth, increases chemotherapy sensitivity, and restores osteoblastic differentiation.
ZEB1 deletion in vivo hinders tumor growth and metastasis while decreasing pro-tumoral macrophage infiltration.
Gene expression profiling shows ZEB1 suppresses oncogenic pathways and inflammatory mediators; its restoration rescues the aggressive phenotype.
Targeting ZEB1 and differentiation-based strategies may offer promising therapeutic avenues for osteosarcoma treatment.

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