P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis - PubMed
6 hours ago
- #cardiac senescence
- #mitophagy
- #P2X7R
- P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis.
- P2X7R expression increases with age in humans and is upregulated in cardiac senescence in mice.
- P2X7R knockout (P2X7R-/-) mice show reduced ageing-related cardiac dysfunction and improved mitophagy.
- Cardiomyocyte-specific P2X7R overexpression worsens myocardial dysfunction and senescence phenotypes.
- P2X7R promotes HuR nucleocytoplasmic shuttling, increasing TRIM26 mRNA stability and expression.
- TRIM26 mediates NR4A1 ubiquitination, leading to its degradation and suppression of mitophagy.
- The study identifies the HuR/TRIM26/NR4A1 axis as a key pathway in cardiac ageing.