A 'two-in-one' tumor-specific-hydrogel-assisted strategy for intravesical chemotherapy and protection of normal tissues - PubMed
6 hours ago
- #intravesical therapy
- #bladder cancer
- #tumor-specific hydrogel
- A 'two-in-one' strategy using a tumor-specific hydrogel for intravesical chemotherapy and normal tissue protection.
- The hydrogel acts as a size-selective filter, allowing sustained drug action while excluding larger entities.
- Cell membrane-derived nanovesicles deliver cytotoxic or protective agents with high selectivity.
- The approach achieves 98% tumor inhibition and reduces inflammation in normal urothelium by 97%.
- Ethical approvals were obtained from Zhejiang Provincial People’s Hospital for animal procedures.
- No competing interests declared by the authors.