Dietary tryptophan enhances aryl hydrocarbon receptor activation and reduces colitis through microbial metabolism - PubMed
3 days ago
- #microbiome
- #tryptophan metabolism
- #aryl hydrocarbon receptor
- Impaired microbial tryptophan metabolism and aryl hydrocarbon receptor (AhR) activation are linked to inflammatory bowel disease (IBD).
- Dietary tryptophan supplementation enhances microbial production of AhR agonists, restoring AhR activation and reducing colitis severity in preclinical models.
- Co-colonization with tryptophan-metabolizing bacteria like Clostridium sporogenes improves tryptophan metabolism and colitis outcomes.