Nuclear AGO2 exacerbates heart failure with preserved ejection fraction through myocardial ketogenesis - PubMed
12 hours ago
- #AGO2
- #HFpEF
- #ketogenesis
- Nuclear AGO2 worsens heart failure with preserved ejection fraction (HFpEF) by promoting myocardial ketogenesis.
- A high-fat diet (HFD) increases the incidence of HFpEF, which involves microRNAs (miRNAs) and lipid metabolism.
- Knockdown of AGO2 or HMGCS2 protects against HFD-induced cardiac dysfunction by reducing β-hydroxybutyrate (β-OHB) overproduction.
- A PKCα-ERK-EGR1-AGO2-HMGCS2 axis is identified in fatty acid-induced cardiomyocyte dysfunction.
- Overexpression of nuclear AGO2 exacerbates HFD-induced cardiac dysfunction, suggesting a potential therapeutic target for HFpEF.